Why weight regain is a predictable biological response after stopping GLP-1s

Obesity medicine physician Jessica Duncan discusses the article "GLP-1 weight regain: Why stopping medication leads to weight return." Jessica explains that expecting to maintain weight loss after abruptly stopping GLP-1 therapy is unrealistic because it ignores the physiological forces that defend a person's prior weight. She critiques a marketplace that often treats these powerful medications as consumer products rather than chronic disease therapies, noting the risks of obtaining prescriptions through brief online questionnaires without ongoing medical oversight. The conversation highlights the complexity of appetite regulation and metabolism, emphasizing that obesity must be managed as a chronic condition rather than a short term problem to be solved. Jessica advocates for longitudinal care relationships and individualized plans that address hunger cues, sleep, and food environment to prevent weight return. Discover why mistaking predictable biology for personal failure is the greatest hurdle in modern obesity care.

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